Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice.
Martino MR, Habibi M, Ferguson D, Brookheart RT, Thyfault JP, Meyer GA, Lantier L, Hughey CC, Finck BN.
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00258.2023. PMID: 38353639
Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51.
Mousa MG, Vuppaladhadiam L, Kelly MO, Pietka T, Ek S, Shen KC, Meyer GA, Finck BN, Brookheart RT.
Cell Rep. 2023 Mar 31;42(4):112336. doi: 10.1016/j.celrep.2023.112336.
PMID: 37002920
Increasing diversity, equity, and inclusion in the fields of nutrition and obesity: A roadmap to equity in academia.
Martin SL, Cardel MI, Carson TL, Hill JO, Stanley T, Grinspoon S, Steger F, Blackman Carr LT, Ashby-Thompson M, Stewart D, Ard J; …Brookheart R.
Am J Clin Nutr. 2023 Apr;117(4):659-671. doi: 10.1016/j.ajcnut.2023.02.001. PMID: 36907515
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.
McGuire MR, Mukhopadhyay D, Myers SL, Mosher EP, Brookheart RT, Kammers K, Sehgal A, Selen ES, Wolfgang MJ, Bumpus NN, Espenshade PJ.
J Biol Chem. 2021 Nov;297(5):101316. doi: 10.1016/j.jbc.2021.101316.
PMID: 34678314
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN.
JCI Insight. 2021 May 10;6(9):e134340. doi: 10.1172/jci.insight.134340. PMID: 33986192
Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility.
Franczyk MP, Qi N, Stromsdorfer KL, Li C, Yamaguchi S, Itoh H, Yoshino M, Sasaki Y, Brookheart RT, Finck BN, DeBosch BJ, Klein S, Yoshino J.
Endocrinology. 2021 Mar 1;162(3):bqab006. doi: 10.1210/endocr/bqab006. PMID: 33543238
A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema.
Schweitzer GG, Gan C, Bucelli RC, Wegner D, Schmidt RE, Shinawi M, Finck BN, Brookheart RT.
Mol Genet Genomic Med. 2019 Jul;7(7):e00733. doi: 10.1002/mgg3.733. PMID: 31070020
Association between obesity and bacterial vaginosis as assessed by Nugent score.
Brookheart RT, Lewis WG, Peipert JF, Lewis AL, Allsworth JE.
Am J Obstet Gynecol. 2019 May;220(5):476.e1-476.e11. doi: 10.1016/j.ajog.2019.01.229. PMID: 30707966
High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster.
Brookheart RT, Swearingen AR, Collins CA, Cline LM, Duncan JG.
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1255-1263. doi: 10.1016/j.bbadis.2017.03.014.
PMID: 28344128
Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster.
Brookheart RT, Duncan JG. Reproduction. 2016 Sep;152(3):R79-90. doi: 10.1530/REP-15-0595. PMID: 27450801
Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity.
Brookheart RT, Duncan JG. Mol Cell Endocrinol. 2016 Nov 5;435:20-28. doi: 10.1016/j.mce.2015.12.003. PMID: 26687062